The Philadelphia Eagles are coming off a season in which they were one of the league’s best teams, and the Browns are coming into the season with a 3-1 record and a bye in the playoffs.
It will be interesting to see how the teams handle their first-round bye, and how the Eagles and Browns will adjust after that.
Here are some other things to watch for as the teams face off this weekend: Who is going to be the Eagles’ best offensive weapon?
We know that the Eagles are going to get Ezekiel Elliott back from a knee injury, but is he really the best pass-catching running back in the NFL?
Is Carson Wentz a threat to go all-out, or is he just a backup who should not be drafted?
Will DeSean Jackson be able to handle his role as the Eagles No. 1 receiver?
What’s the Eagles biggest weakness at running back?
What does it mean for the Eagles if rookie running back Devontae Booker is lost for the year?
What are the chances of the Eagles going for the Super Bowl this season?
How much is too much for the Browns to get?
The Eagles and Eagles fans have been waiting a long time for the first matchup of the 2017 season, but the Eagles were not able to take advantage of the bye this season.
They will need to find a way to beat the Browns in Week 2, and that could be difficult.
Who will be the Browns’ best defensive player?
Let’s face it, Cleveland was one of NFL’s best defenses last season.
Is they still one of its best?
Will Cleveland’s defense be able and willing to stop the Eagles from throwing the ball more often?
How does DeShone Kizer fare against the Eagles?
Who is the Browns top tight end?
Will the Eagles be able get open against Cleveland’s top tight ends?
Who will lead the Browns defense?
What will the Eagles secondary do?
Is Cleveland’s pass rush as dominant as it has been in recent years?
Who has been the most impressive player for Cleveland?
Who have the Browns been able to get to the quarterback?
Who can get to LeSean McCoy and make a big play on the football?
Who should be the top receiver for Cleveland in Week 3?
Who might be the biggest threat to make the Eagles offense work against the Browns?
Is the Browns offense going to come apart if a lot of running back injuries occur?
Will LeSean Jackson, Zach Ertz and Zach Ertlesen be able play on a full schedule?
What should be a tough matchup for Cleveland, especially with their bye week coming up, and who will be able make the most of it?
Who could be the best receiver in the game?
Who else will be involved in the Cleveland offense?
Who’s the best player on the Browns this season, and why?
Who are the biggest storylines for Cleveland this season and how can we watch for them to win in Week 4?
Who in the league could take the crown away from the Eagles in Week 1?
The NFL Week 2 schedule is set to kick off Sunday, Oct. 4 at 11:30 a.m.
ET on NBC, and you can watch it on NBC Sports Live Extra.
Check out our NFL schedule page for more details on all of the games.